ScienceDirect - Tetrahedron Letters : New approach to the synthesis of deoxynucleoside-phosphoramidite derivatives

Tetrahedron Letters
Volume 27, Issue 2, 1986, Pages 199-202

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doi:10.1016/S0040-4039(00)83976-3

New approach to the synthesis of deoxynucleoside-phosphoramidite derivatives

Toshiki Tanaka, Sigeru Tamatsukuri and Morio Ikehara

Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565, Japan

Received 2 November 1985.

Available online 8 March 2001.

Abstract

A new method for the synthesis of deoxyribonucleoside-phosphoramidite via an intermediate, 5′-0-dimethoxytritylthymidine-3′-0-diisopropylamino-phosphorochloridite, is reported. By using this method, several deoxyribonucleoside phosphoramidite derivatives with different protecting groups at phosphorus including P---S and P---N bond besides P---O bond were synthesized.

References

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³¹P NMR spectra was measured in CDCl₃. Trimethylphosphate was used as the external standard.

Tetrahedron Letters
Volume 27, Issue 2, 1986, Pages 199-202

Result list | previous < 20 of 36 > next

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